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KMID : 0356019940090010033
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Koean Jounral of Critical Care Medicine
1994 Volume.9 No. 1 p.33 ~ p.38
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Effect of Intraarterial Injection of Thiopental Sodium on the Posterior Auricular Arterial Bed in the Rabbits
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Abstract
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Thiopental sodium is the most frequently used induction agent in general anesthesia. Prepared as 2.5% solution in distilled water, thiopental sodium is a very strong alkaline solution, is pH being 10.5. As a result, an accidental intra-arterial
injection or extravascular injection of thiopental sodium may cause chemical endarteritis which destroys the vascular bed and muscular layer in severe case
This study was undertaken to evaluate the effects of the intraarterial injection of thiopental sodium on changes in posterior auricular arterial vessels in rabbits.
In this study, we injected 2.5% thiopental sodium(5mg/kg) to the posterior auricular artery of the ravbbit and observed the changes in the arterial tissues after 24 hours and 7 days after injection.
@ES The results were as follows:
@EN 1) There was no gross changes in the skin of injected area 24 hours after injection. Neither endothelial and vasollar changes were noticed as compared to the site not injection with thiopental sodium.
2) Three days later, the skin of injected area became reddish, edematous lesion(1.5cm)and showed diffuse thiombosis within the vessel.
3) Seven days after the intraarterial injection of thiopental sodium, the skin of the injected area changed to brown color and a crust formed. In addition, the vessel was diffusely occluded by thrombosis.
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